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Development of small-molecule viral inhibitors targeting various stages of the life cycle of emergingand re-emerging viruses

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 449-461 doi: 10.1007/s11684-017-0589-5

摘要：

In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus. These viruses can interfere with the specific steps of viral life cycle by blocking the binding between virus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viral RNA replication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging viruses. We also discuss some general strategies for developing small-molecule viral inhibitors.

关键词： emerging and re-emerging viruses     small-molecule inhibitor     coronavirus     Ebola virus     Zika virus     life cycle    

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Responses to emerging and re-emerging infectious diseases: One world, One health

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《医学前沿（英文）》 2018年 第12卷 第1期   页码 1-2 doi: 10.1007/s11684-018-0619-y

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Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

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《医学前沿（英文）》 2018年 第12卷 第1期   页码 3-22 doi: 10.1007/s11684-017-0605-9

摘要：

For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing. Nevertheless, frequent infectious disease outbreaks/events have been reported almost every year, and imported infectious diseases have increased since 2015. New pathogens and over 100 new genotypes or serotypes of known pathogens have been identified. Some infectious diseases seem to be exacerbated by various factors, including rapid urbanization, large numbers of migrant workers, changes in climate, ecology, and policies, such as returning farmland to forests. This review summarizes the current experiences and lessons from China in managing emerging and re-emerging infectious diseases, especially the effects of ecology, climate, and behavior, which should have merits in helping other countries to control and prevent infectious diseases.

关键词： infectious disease profile     emerging infectious diseases     influence factor    

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Construction of MOFs-based nanocomposite membranes for emerging organic contaminants abatement in water

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1689-x

摘要：

● Application of the MOF-composite membranes in adsorption was discussed.

关键词： Emerging organic contaminants     Metal organic frameworks     Synthesis     Adsorption     Catalysis    

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An emerging market for groundwater remediation in China: Policies, statistics, and future outlook

Deyi Hou, Guanghe Li, Paul Nathanail

《环境科学与工程前沿（英文）》 2018年 第12卷 第1期 doi: 10.1007/s11783-018-1027-x

摘要： There is a rapidly emerging and potentially huge market for the remediation of contaminated groundwater in China. The Chinese government published a Water Action Plan in April 2015, a Soil Action Plan in May 2016, and a draft Soil Pollution Prevention and Control Law in June 2017. All of these new policies and regulations put pressures on local governments and contaminated site owners, obliging them to conduct site investigation and to cleanup contaminated groundwater. The Chinese population in northern regions heavily depend on groundwater, with nearly 70% of water supply coming from aquifer sources in the Beijing-Tianjin-Hebei region. However, poor groundwater quality due to natural geochemical background and anthropogeic pollution is a serious concern, with poor or very poor quality water observed in nearly 80% of groundwater monitoring wells in 17 northern provinces. Shallow groundwater in many areas has been contaminated by toxic pollutants such as heavy metals and chlorinated organic compounds. There is an urgent need to better understand the situation and to conduct groundwater remediation at contaminated sites. The Chinese government is investing heavily in the research and development for groundwater remediation, which is expected to greatly add to the quality and quantity of groundwater remediation projects in the near future.

关键词： Groundwater pollution     Contaminated land     Groundwater remediation     Emerging market    

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Integrated risk assessment framework for transformation products of emerging contaminants: what we know

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1691-3

摘要：

● A better risk assessment can combine the improved non-target analysis method.

关键词： Risk assessment frameworks     Transformation products     Emerging contaminants     High-throughput toxicity screening     Water treatment    

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Bridging science, technology and policy in emerging contaminants control

《环境科学与工程前沿（英文）》 2023年 第17卷 第5期 doi: 10.1007/s11783-023-1665-5

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Hierarchically porous materials: Synthesis strategies and emerging applications

Minghui Sun, Chen Chen, Lihua Chen, Baolian Su

《化学科学与工程前沿（英文）》 2016年 第10卷 第3期   页码 301-347 doi: 10.1007/s11705-016-1578-y

摘要： Great interests have arisen over the last decade in the development of hierarchically porous materials. The hierarchical structure enables materials to have maximum structural functions owing to enhanced accessibility and mass transport properties, leading to improved performances in various applications. Hierarchical porous materials are in high demand for applications in catalysis, adsorption, separation, energy and biochemistry. In the present review, recent advances in synthesis routes to hierarchically porous materials are reviewed together with their catalytic contributions.

关键词： hierarchically porous materials     synthesis     application    

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Advanced biomass materials: progress in the applications for energy, environmental, and emerging fields

《化学科学与工程前沿（英文）》 2023年 第17卷 第7期   页码 795-797 doi: 10.1007/s11705-023-2336-6

摘要： Advanced biomass materials: progress in the applications for energy, environmental, and emerging fields

关键词： progress applications energy     fields    

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能源新技术新兴产业发展动态与 2035 战略对策

张博,孙旭东,刘颖,彭苏萍

《中国工程科学》 2020年 第22卷 第2期   页码 38-46 doi: 10.15302/J-SSCAE-2020.02.006

摘要：

技术创新深刻影响着全球能源工业的转型发展，发展能源领域新兴产业是立足我国国情现实，满足国家重大战略需求，实现技术创新驱动能源产业发展的需要。本文界定的“能源新技术”不仅涉及可再生能源和核能领域，而且涵盖非常规油气资源开发、传统化石能源的清洁高效转化与利用、能源传输以及终端用能等领域，是具有突破性或颠覆性的能源开发利用技术。在此基础上，明确了能源新技术新兴产业的范畴与定位，分析了当前国内外能源新技术新兴产业发展的现状与趋势，研判了面向 2035 年的能源新技术新兴产业重点领域与技术方向，详细论述了“十四五”时期我国能源新技术新兴产业发展的思路、目标与重点任务。研究提出：我国应着重发展先进燃煤发电、非常规天然气开发、能源互联网与综合能源服务、核能、风力发电、太阳能光伏发电、太阳能光热发电、生物质能、地热能、氢能源与燃料电池等 10 个领域 41 项能源新技术；建议设立 9 项工程科技攻关项目、 1 项多能互补分布式能源重大工程以及河北雄安新区和华南沿海地区两个能源新技术集成创新示范区；完善能源新技术及产业发展的顶层设计，并入节能产业，将战略性新兴产业中的“新能源产业”调整为“能源新技术产业”。

关键词： 能源工业     能源新技术     新兴产业     2035    

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Emerging contaminant control: From science to action

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-022-1559-y

摘要： Since the concept of emerging contaminants (ECs) was first proposed in 2001, the global scientific research of ECs has developed rapidly. In the past decades, great progress has been achieved in the scientific research of ECs in China, including the establishment of EC analysis method system, the evaluation of the pollution status, pollution characteristics and environmental risk of ECs in typical regions of China, and establishment of EC control technology system. Continuous progress in scientific research of ECs promoted China’s action on EC control. It is planned that the environmental risk of ECs will be generally controlled by 2035 in China. Priority ECs should be screened for environmental management. Although great efforts have been made, the EC control in China still faces tremendous challenges. It is necessary to bridge the gap between scientific research and decision-making management. Based on the science and technology study, various measures such as engineering, policy management and public participation should be combinedly adopted for EC control.

关键词： Emerging contaminants     Priority pollutants     PPCPs     POPs     Control policy    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 462-470 doi: 10.1007/s11684-017-0596-6

摘要：

The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.

关键词： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Passive antibody therapy in emerging infectious diseases

《医学前沿（英文）》 doi: 10.1007/s11684-023-1021-y

摘要： The epidemic of corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 and its variants of concern (VOCs) has been ongoing for over 3 years. Antibody therapies encompassing convalescent plasma, hyperimmunoglobulin, and neutralizing monoclonal antibodies (mAbs) applied in passive immunotherapy have yielded positive outcomes and played a crucial role in the early COVID-19 treatment. In this review, the development path, action mechanism, clinical research results, challenges, and safety profile associated with the use of COVID-19 convalescent plasma, hyperimmunoglobulin, and mAbs were summarized. In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights into the coping strategies for facing new infectious disease outbreaks.

关键词： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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Effectiveness of tertiary treatment processes in removing different classes of emerging contaminants

《环境科学与工程前沿（英文）》 2022年 第16卷 第11期 doi: 10.1007/s11783-022-1583-y

摘要：

● Different advanced treatment processes were tested for ECs removal from wastewater.

关键词： Micropollutants     Wastewater     PAC     Membranes     UV     Tertiary treatment    

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Fate and risk assessment of emerging contaminants in reclaimed water production processes

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1392-8

摘要：

• PPCPs had the highest removal efficiency in A2O combined with MBR process (86.8%).

关键词： Trace organic pollution     Antibiotic resistance genes     Reclaimed wastewater     Sludge     Risk assessment     Mass load    

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标题 作者 时间 类型 操作

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emergingand re-emerging viruses

null

期刊论文

Responses to emerging and re-emerging infectious diseases: One world, One health

null

期刊论文

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

null

期刊论文

Construction of MOFs-based nanocomposite membranes for emerging organic contaminants abatement in water

期刊论文

An emerging market for groundwater remediation in China: Policies, statistics, and future outlook

Deyi Hou, Guanghe Li, Paul Nathanail

期刊论文

Integrated risk assessment framework for transformation products of emerging contaminants: what we know

期刊论文

Bridging science, technology and policy in emerging contaminants control

期刊论文

Hierarchically porous materials: Synthesis strategies and emerging applications

Minghui Sun, Chen Chen, Lihua Chen, Baolian Su

期刊论文

Advanced biomass materials: progress in the applications for energy, environmental, and emerging fields

期刊论文

能源新技术新兴产业发展动态与 2035 战略对策

张博,孙旭东,刘颖,彭苏萍

期刊论文

Emerging contaminant control: From science to action

期刊论文

Human monoclonal antibodies as candidate therapeutics against emerging viruses

null

期刊论文

Passive antibody therapy in emerging infectious diseases

期刊论文

Effectiveness of tertiary treatment processes in removing different classes of emerging contaminants

期刊论文

Fate and risk assessment of emerging contaminants in reclaimed water production processes

期刊论文